Scientific Publications

Selected Senomyx Publications

Hanghui Liu, Lily Lam, Purnendu K. Dasgupta, (2011) Expanding the linear dynamic range for multiple reaction monitoring in quantitative liquid chromatography–tandem mass spectrometry utilizing natural isotopologue transitions doi:10.1016/j.talanta.2011.09.063

Servant, G., Tachdjian, C and Li, X. (2010) Small Molecule Modulators of Family-C Taste GPCRs. In Igaku No Ayumi (Journal of Clinical and Experimental Medicine) volume 233 No. 9. Editor: Iiri, T. Ishiyaku Pub pp 881-891.

Zhang, F., Klebansky, B., Fine, R.M., Haitian, L., Xu, H., Servant, G., Zoller, M., Tachdjian, C., and Li, X. (2010) Molecular Mechanism of the Sweet Taste Enhancers. PNAS 2010 www.pnas.org/cgi/doi/10.1073/pnas.0911660107

Servant, G. Tachdjian, C., Tang, X., Werner, S., Feng, Z., Li, X., Kamdar, P., Petrovic, G., Ditschun, T., Java, A., Brust, P., Brune, N., DuBois, G., Zoller, M., and Karanewsky, D.S. (2010) Positive Allosteric Modulators of the Human Sweet Taste Receptor Enhance Sweet Taste. PNAS 2010 www.pnas.org/cgi/doi/10.1073/pnas.0911670107

Zhang, F., Klebansky, B., Fine, R.M., Xu, H., Pronin, A., Liu, H., Tachdjian, C., and Li, X. (2008) Molecular mechanism for the umami taste synergism. Proc. Natl. Acad. Sci. USA. 106:52:20930–20934.

Pronin, A.N., Xu, H., Tang, H., Zhang, L., Li, Q., and Li, X. (2007). Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin. Current Biology. 17:16:1403-1408.

Pronin, A.N., Tang, H., Connor, J., and Keung, W. (2004). Identification of ligands for two human bitter T2R receptors. Chem Senses. 29:583-593.

Xu, H., Staszewski, L., Tang, H., Adler, E., Zoller, M., and Li, X. (2004). Different functional roles of T1R subunits in the heteromeric taste receptors. Proc. Natl. Acad. Sci. USA, 101:14258-14263.

Li, X., Staszewski, L., Xu, H., Durick, K., Zoller, M., Adler, E. (2002). Human receptors for sweet and umami taste. Proc. Natl. Acad. Sci. U.S.A. 99, 4692-4696.

Ozeck, M., Brust, P., Xu, H., and Servant, G. (2004) Receptors for bitter, sweet and umami taste couple to inhibitory G protein signaling pathways. Eur J Pharmacol. 489:139-149.

Pronin, A.N., Tang, H., Connor, J., and Keung, W. (2004). Identification of ligands for two human bitter T2R receptors. Chem Senses. 29:583-593.

Lu, M., Staszewski, L., Echeverri, F., Xu, H., and Moyer, B.D. (2004). Endoplasmic reticulum degradation impedes olfactory G-protein coupled receptor functional expression. BMC Cell Biol. 5:34-44

Lu, M., Echeverri, F., and Moyer, B.D. (2003) Endoplasmic reticulum retention, degradation, and aggregation of olfactory G-protein coupled receptors. Traffic, 4:416-433.

Zozulya, S., Echeverri, F., Nguyen, T. (2001) The human olfactory receptor repertoire. Genome Biol. 2:RESEARCH0018.


Selected Publications by Senomyx Scientific Advisory Board

Tsien, R.Y. (1989) Fluorescent probes of cell signaling. Annu. Rev. Neurosci. 12, 227-253

Hoon, M.A., Adler, E., Lindemeier, J., Battey, J.F., Ryba, N.J., Zuker, C.S. (1999). Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity. Cell 96, 541-51.

Adler, E., Hoon, M.A., Mueller, K.L., Chandrashekar, J., Ryba, N.J., Zuker, C.S. (2000). A novel family of mammalian taste receptors. Cell 100, 693-702.

Chandrashekar, J., Mueller, K.L., Hoon, M,A., Adler, E., Feng, L., Guo, W., Zuker, C.S., Ryba, N.J. (2000). T2Rs function as bitter taste receptors. Cell 100, 703-711.

Nelson, G., Hoon, M.A., Chandrashekar, J., Zhang, Y., Ryba, N.J., Zuker, C.S. (2001). Mammalian sweet taste receptors. Cell 106, 381-90.

Nelson, G., Chandrashekar, J., Hoon, M.A., Feng, L., Zhao, G., Ryba, N.J., Zuker, C.S. (2002). An amino-acid taste receptor. Nature 416, 199-202.

Zhang, Y., Hoon, M.A., Chandrashekar, J., Mueller, K.L., Cook, B., Wu, D., Zuker, C.S., Ryba, N.J. (2003). Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell 112, 293-301.

Zhao, G.Q., Zhang, Y., Hoon, M.A., Chandrashekar, J., Erlenbach, I., Ryba, N.J., Zuker, C.S. (2003). The receptors for mammalian sweet and umami taste. Cell 115, 255-66.