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Scientific Publications

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Selected Senomyx Publications



Servant, G., Tachdjian, C and Li, X. (2010) Small Molecule Modulators of Family-C Taste GPCRs. In Igaku No Ayumi (Journal of Clinical and Experimental Medicine) volume 233 No. 9. Editor: Iiri, T. Ishiyaku Pub pp 881-891.

Zhang, F., Klebansky, B., Fine, R.M., Xu, H., Pronin, A., Liu, H., Tachdjian, C., and Li, X. (2008) Molecular mechanism for the umami taste synergism. Proc. Natl. Acad. Sci. USA. 106:52:2093020934.

Pronin, A.N., Xu, H., Tang, H., Zhang, L., Li, Q., and Li, X. (2007). Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin. Current Biology. 17:16:1403-1408.

Pronin, A.N., Tang, H., Connor, J., and Keung, W. (2004). Identification of ligands for two human bitter T2R receptors. Chem Senses. 29:583-593.

Xu, H., Staszewski, L., Tang, H., Adler, E., Zoller, M., and Li, X. (2004). Different functional roles of T1R subunits in the heteromeric taste receptors. Proc. Natl. Acad. Sci. USA, 101:14258-14263.

Li, X., Staszewski, L., Xu, H., Durick, K., Zoller, M., Adler, E. (2002). Human receptors for sweet and umami taste. Proc. Natl. Acad. Sci. U.S.A. 99, 4692-4696.

Ozeck, M., Brust, P., Xu, H., and Servant, G. (2004) Receptors for bitter, sweet and umami taste couple to inhibitory G protein signaling pathways. Eur J Pharmacol. 489:139-149.

Pronin, A.N., Tang, H., Connor, J., and Keung, W. (2004). Identification of ligands for two human bitter T2R receptors. Chem Senses. 29:583-593.

Lu, M., Staszewski, L., Echeverri, F., Xu, H., and Moyer, B.D. (2004). Endoplasmic reticulum degradation impedes olfactory G-protein coupled receptor functional expression. BMC Cell Biol. 5:34-44

Lu, M., Echeverri, F., and Moyer, B.D. (2003) Endoplasmic reticulum retention, degradation, and aggregation of olfactory G-protein coupled receptors. Traffic, 4:416-433.

Zozulya, S., Echeverri, F., Nguyen, T. (2001) The human olfactory receptor repertoire. Genome Biol. 2:RESEARCH0018.


Selected Publications by Senomyx Scientific Advisory Board

Tsien, R.Y. (1989) Fluorescent probes of cell signaling. Annu. Rev. Neurosci. 12, 227-253

Hoon, M.A., Adler, E., Lindemeier, J., Battey, J.F., Ryba, N.J., Zuker, C.S. (1999). Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity. Cell 96, 541-51.

Adler, E., Hoon, M.A., Mueller, K.L., Chandrashekar, J., Ryba, N.J., Zuker, C.S. (2000). A novel family of mammalian taste receptors. Cell 100, 693-702.

Chandrashekar, J., Mueller, K.L., Hoon, M,A., Adler, E., Feng, L., Guo, W., Zuker, C.S., Ryba, N.J. (2000). T2Rs function as bitter taste receptors. Cell 100, 703-711.

Nelson, G., Hoon, M.A., Chandrashekar, J., Zhang, Y., Ryba, N.J., Zuker, C.S. (2001). Mammalian sweet taste receptors. Cell 106, 381-90.

Nelson, G., Chandrashekar, J., Hoon, M.A., Feng, L., Zhao, G., Ryba, N.J., Zuker, C.S. (2002). An amino-acid taste receptor. Nature 416, 199-202.

Zhang, Y., Hoon, M.A., Chandrashekar, J., Mueller, K.L., Cook, B., Wu, D., Zuker, C.S., Ryba, N.J. (2003). Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell 112, 293-301.

Zhao, G.Q., Zhang, Y., Hoon, M.A., Chandrashekar, J., Erlenbach, I., Ryba, N.J., Zuker, C.S. (2003). The receptors for mammalian sweet and umami taste. Cell 115, 255-66.


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