Current Flavor Programs

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Flavor Ingredient Programs

We are currently pursuing the discovery and development of new flavor ingredients in the savory, sweet, salt, and cool taste areas, as well as ingredients that block bitter taste.

Senomyx Flavor Programs Glossary:
To be consistent with industry usage and key global flavor regulatory authorities, Senomyx refers to flavor ingredients that modify other flavors or other dietary components as “modifiers.”

Senomyx has created brand names for flavor ingredients that the Company will commercialize under its direct sales initiative. The umbrella brand for the taste modulation ingredients to be marketed by Senomyx, Complimyx
®, was selected to connote the benefits of using these offerings to add value to flavor systems. Under the Complimyx® brand, each taste category is identified separately, such as Sweetmyx™ for Senomyx’s sweet taste modifiers and Savorymyx™ for the Company’s savory flavors. Specific ingredients within a taste category are referenced using a category code. For example, the first offering for Senomyx’s direct sales initiative will be Sweetmyx SR96, which is also known as the sucrose modifier S9632.

Sweet Taste Program

Sucralose Modifier S2383 Flavor ingredient with modifying properties that is used to restore the desired taste profile of
products in which sucralose, a commonly used high-intensity sweetener, has been reduced
Sucrose Modifier S6973 Flavor ingredient with modifying properties that is used to restore the desired taste profile of products in which sucrose (table sugar) has been reduced

SR96 (S9632)
Flavor ingredient with modifying properties that is used to restore the desired taste profile of
products in which sucrose (table sugar) has been reduced

Sweet Taste Modifier S617

Flavor ingredient with modifying properties that is in development; intended to restore the
desired taste profile of products in which sweeteners have been reduced

Savory Taste Program

Savory Flavors S336, S643, & additional ingredients

UM80 (S807)
Flavor ingredients that are very versatile and can be used to create new savory blends

Bitter Blocker Program

Bitter Blockers S6821 S7958

Flavor ingredients with modifying properties that are used in foods and beverages to reduce
the bitterness of bitter tasting ingredients, e.g., soy & whey proteins, menthol, caffeine,
cocoa, Rebaudioside A (stevia)

Cooling Taste Program

Cooling Agents S2227 Flavor ingredient that is in development; intended to overcome the limitations of currently available agents, e.g., by having greater potency, longer cooling duration, or lack of aroma

Savory Taste Program
All of Senomyx's Savory Flavors have GRAS (Generally Recognized As Safe) regulatory approval, which allows commercialization in the U.S. and other countries. Some also have approval in additional countries including the European Union and China, the world's largest MSG market. Nestlé SA, the world's largest food company, and another Senomyx collaborator are currently marketing new and reformulated products that incorporate a Senomyx Savory Flavor. The marketed products have been launched into the retail, industrial, and food service channels in selected countries within Africa, Asia, Latin America, and the Middle East. Four of the Savory Flavors were approved for use in European Union countries as of April 2013.

Senomyx will be marketing Savorymyx UM80 (S807) as part of our direct sales product portfolio. Savorymyx UM80 has regulatory approvals in the U.S. and virtually everywhere in the world. It is currently being evaluated by flavor companies for use in numerous food and beverage product categories.

Sweet Taste Program
The primary goal for Senomyx’s Sweet Taste Program is to identify flavor ingredients that allow a significant reduction of sweeteners in food and beverage products while maintaining the desired sweet taste. Senomyx has two partners for this program – PepsiCo, the world’s second-largest food and beverage business, and Firmenich SA, a global leader in providing ingredients and flavor systems to major consumer companies.

Senomyx has three ingredients with sweet flavor modifying properties that have received regulatory approvals and are available for commercialization under license agreements with Firmenich.

S2383 is a novel sweet taste modifier that can be used to restore the desired taste profile of products in which up to 75% of the sucralose, a commonly used high-intensity sweetener, has been reduced. Use of S2383 maintains the sweet intensity of the product without producing off-tastes. In addition, S2383 may result in an improved taste compared to sucralose alone when incorporated into a flavor system.

Sucralose is used in a wide variety of beverages and foods such as confectionaries, baked goods, desserts, and dairy products, as well as over-the-counter (OTC) healthcare products and dietary supplements. S2383 has been granted a GRAS regulatory designation that allows commercialization in the U.S. and other countries, as well as approval in the European Union and a positive determination from JECFA, which is recognized by additional countries. Products that contain S2383 are being marketed for use in all food and beverage product categories in North America and Latin America.

S6973 is a modifier of sucrose (table sugar) that can be used to restore the desired taste profile of foods and selected beverages in which up to 50% of the sucrose has been reduced. Reducing the quantity of sucrose in products could be advantageous for consumers seeking to limit sugar in their diets and for manufacturers that would like to offer products with improved nutritional profiles without compromising on taste. Senomyx received a GRAS designation for S6973 in October 2009. The GRAS designation allows usage of S6973 in baked goods, cereals, gum, condiments and relishes, confectioneries and frostings, frozen dairy offerings, fruit ices, gelatins and puddings, hard and soft candy, jams and jellies, milk products, and sauces. During the first quarter of 2010, the GRAS status for S6973 was extended to instant coffee and tea, and imitation dairy products. S6973 received JECFA approval in the third quarter of 2012.

Commercialization activities with S6973 are being conducted in the Americas, Southeast Asia, Africa, and Australia. Market launches of retail products that incorporate S6973 have occurred in the U.S., Latin America, Asia, and South Africa. These products span a variety of categories including ready-to-drink and powdered beverages, dairy products, and baked goods.

Senomyx’s Sweetmyx™ SR96 (S9632) sucrose modifier was granted a Generally Recognized As Safe (GRAS) regulatory designation during the third quarter of 2012. Like the S6973 sucrose modifier, SR96 can be used to restore the desired taste profile of products in which in which up to 50% of the sucrose has been reduced, providing a solution for manufacturers seeking to create new offerings that have significantly lower sugar and calories, but retain the sugar taste consumers enjoy. SR96 is applicable for use in alcoholic beverages as well as a broader range of non-alcoholic beverages that includes powdered and concentrated beverages, along with ready-to-drink and powdered forms of dairy, coffee and tea products.

Sweetmyx SR96 will be the first product sold under Senomyx’s direct sales initiative. It is currently being demonstrated to flavor companies for end-use in non-alcoholic beverages and powdered beverages. Firmenich has exclusive rights during their “period of exclusivity” to commercialize SR96 for food applications and shares co-exclusive rights with Senomyx for powdered beverages.

S617, a new modifier for both high fructose corn syrup (HFCS) and sucrose, is currently in the development phase. High fructose corn syrup is a widely used sweetener, especially in North America. It is used in products such as baked goods, yogurts, sauces and condiments, beverages and concentrates, granola and energy bars, and canned and frozen fruits. The utility of S617 with both HFCS and sucrose could allow manufacturers that use these sweeteners to focus their internal efforts on a single sweet taste modifier, thereby potentially increasing efficiency and cost-effectiveness.

The goal of the Natural Products Initiative of Senomyx’s Sweet Taste Program is to discover and develop novel no- or low-calorie natural high intensity sweeteners and natural sweet taste modifiers. The Company’s approach was validated with the identification of its first natural sucrose modifier and the identification of a natural component that provided a sweet taste, which are important taste-proofs-of-concept for the program.

Bitter Blockers Program
The primary goals of Senomyx's Bitter Blocker Program are to reduce or block bitter taste and to improve the overall taste characteristics of foods, beverages, and ingredients. Reducing bitterness would be valuable for the many manufacturers who want to improve the taste characteristics of foods, beverages, healthcare items, and other products.

Senomyx received GRAS regulatory designations for two Bitter Blockers, S6821 and S7958, in the fourth quarter of 2010, and positive JECFA determinations in the third quarter of 2012. S6821 has demonstrated activity against bitter tasting foods and beverages that include soy and whey proteins, menthol, caffeine, cocoa, and Rebaudioside A (stevia). S7958, a related bitter blocker with similar functionality, has alternative desirable physical properties that may be useful for these or other product applications.

A Senomyx partner has initiated market launch of a retail product incorporating S6821 in a country in Southeast Asia. S6821 is currently being used in several products in this country. Marketing is continuing and the partner is currently evaluating the use of S6821 in additional products and geographies.

Salt Taste Program
The goal of our Salt Taste Program is to identify flavor ingredients that allow a significant reduction of sodium in foods and beverages yet maintain the salty taste desirable to consumers. This program is an important research focus for the Company’s longer-term pipeline. Senomyx has assembled a proprietary database of proteins found in taste buds and progress is being made exploring the role of a number of these proteins that may be involved in salt taste perception. Activities include targeted analytical approaches to discover specific proteins that could be viable candidates for the receptors or co-factors responsible for salt taste. The Company is currently focusing a greater effort on a smaller subset of taste bud proteins that includes potential lead candidates for the salt receptor, as well as candidates involved in signaling the sensory perception of saltiness.

Cooling Taste Program
The goal of Senomyx’s Cooling Taste Program is to identify novel cooling agents that do not have the limitations of currently available agents, which include weak cooling characteristics, bitter off-tastes, limited solubility, and non-proprietary status. S2227, a new cooling agent, has been advanced into definitive safety studies in preparation for future regulatory filings. Firmenich has exclusive commercialization rights for certain selected new flavors developed under the Cooling Taste Program and is currently evaluating these cooling agents for potential future commercialization.

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