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Current Flavor Programs

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Flavor Ingredient Programs

We are currently pursuing the discovery and development of new flavor ingredients in the savory, sweet, salt, and cool taste areas, as well as ingredients that block bitter taste.

Senomyx Flavor Programs Glossary:
To be consistent with industry usage and key global flavor regulatory authorities, Senomyx refers to flavor ingredients that modulate other flavors or dietary components as “flavors with modifying properties” or “modifiers.”

Senomyx has created brand names for flavor ingredients that the Company will commercialize under its direct sales initiative. The umbrella brand for the taste modulation ingredients to be marketed by Senomyx, Complimyx®, was selected to connote the benefits of using these offerings to add value to flavor systems. Under the Complimyx® brand, each taste category is identified separately, such as Sweetmyx® for Senomyx’s sweet flavor modifiers, Savorymyx® for the Company’s savory flavors, and Bittermyx® for ingredients that reduce bitter taste. Specific ingredients within a taste category are referenced using a category code. For example, the first offering for Senomyx’s direct sales initiative will be Sweetmyx SR96, which is also known as S9632.

Sweet Taste Program

Sucralose Modifier S2383 Flavor with modifying properties used as part of a flavor system to restore the desired taste profile of products in which sucralose, a commonly used high-intensity sweetener, has been reduced

sweetmyx
SR69 (S6973)

Flavor with modifying properties used as part of a flavor system to restore the desired taste profile of products in which sucrose (table sugar) has been reduced

sweetmyx
SR96 (S9632
)

Flavor with modifying properties used as part of a flavor system to restore the desired taste profile of products in which sucrose (table sugar) has been reduced

sweetmyx
Flavor Ingredient (S617)

Flavor with modifying properties used as part of a flavor system to restore the desired taste profile of products in which sweeteners have been reduced

Savory Taste Program

Savory Flavors S336 & additional ingredients

SavoryMyx
UM80 (S807)

Flavor ingredients that are very versatile and can be used to create new savory blends

Bitter Blocker Program

Bitter Blockersbittermyx BB68 (S6821)

Flavors with modifying properties used as part of a flavor system for foods and beverages to reduce the bitterness of bitter tasting ingredients, e.g., soy & whey proteins, menthol, caffeine, cocoa, Rebaudioside A (stevia)

Cooling Taste Program

Cooling Agents S2227 Flavor ingredient intended to overcome the limitations of currently available agents, e.g., by having greater potency, longer cooling duration, or lack of aroma


Savory Taste Program
Senomyx’s Savory Flavors provide a distinct new savory (umami) taste sensation and can be combined with other ingredients to create unique new flavor blends. They are applicable for a variety of products including sauces, frozen foods, cooking aids, soups, and snack foods, and can be used to reduce or replace added monosodium glutamate (MSG).

Each of Senomyx's Savory Flavors has FEMA GRAS (Generally Recognized As Safe) regulatory approval, which allows commercialization in the U.S. and other countries. Some also have approvals from JECFA, which evaluates food safety for numerous countries, as well as approvals that allow usage in the European Union and China, the world's largest MSG market.

Nestlé SA, the world's largest food company, and another Senomyx collaborator are currently marketing new and reformulated products that incorporate a Senomyx Savory Flavor. The marketed products have been launched into the retail, industrial, and food service channels in selected countries within Africa, Asia, Latin America, and the Middle East.

Senomyx is marketing Savorymyx UM80 (S807) as part of our direct sales product portfolio. Savorymyx UM80 has regulatory approvals in the U.S. and virtually everywhere in the world. It is currently being evaluated by flavor companies for use in numerous food and beverage product categories.

Sweet Taste Program
The primary goal for Senomyx’s Sweet Taste Program is to identify flavor ingredients that allow a significant reduction of sweeteners in food and beverage products while maintaining the desired sweet taste. Senomyx has two partners for this program – PepsiCo, the world’s second-largest food and beverage business, and Firmenich SA, a global leader in providing ingredients and flavor systems to major consumer companies.

Senomyx has four ingredients with sweet flavor modifying properties that have received regulatory approvals and are available for commercialization. Sweetmyx ingredients are sweet flavor modifiers used with other flavors to restore the desired sweet taste of products in which sucrose or other sweeteners have been reduced. Having multiple Sweetmyx offerings allows us to address specific food or beverage product requirements and broadens the potential applications for Senomyx’s flavor ingredient portfolio.

S2383 is a novel sweet taste modifier that can be used to restore the desired taste profile of products in which up to 75% of the sucralose, a commonly used high-intensity sweetener, has been reduced. Use of S2383 maintains the sweet intensity of the product without producing off-tastes. In addition, S2383 may result in an improved taste compared to s

ucralose alone when incorporated into a flavor system. Sucralose is used in a wide variety of beverages and foods such as confectionaries, baked goods, desserts, and dairy products, as well as over-the-counter (OTC) healthcare products and dietary supplements. S2383 has been granted a FEMA GRAS regulatory designation that allows commercialization in the U.S. and other countries. It has also received approval in the European Union and a positive determination from JECFA, which is recognized by additional countries. Products that contain S2383 are being marketed by Firmenich for use in food and beverage product categories in North America, Latin America, Asia and Europe. .

Sweetmyx SR69 (S6973) is a flavor with modifying properties that can be used to restore the desired taste profile of foods and selected beverages in which sucrose (table sugar) has been reduced. Reducing the quantity of sucrose in products could be advantageous for consumers seeking to limit sugar in their diets and for manufacturers that would like to offer products with improved nutritional profiles without compromising on taste.

Senomyx received a FEMA GRAS designation for SR69 which allows usage of the product in baked goods, cereals, gum, condiments and relishes, confectioneries and frostings, frozen dairy offerings, fruit ices, gelatins and puddings, hard and soft candy, jams and jellies, milk products, and sauces. The FEMA GRAS status was later extended to include instant coffee and tea, and imitation dairy products. In 2014 alcoholic beverages were added to the list of FEMA GRAS-designated product categories for SR69. Senomyx has also received JECFA approval for SR69 allowing usage in many new international markets. Earlier this year Senomyx announced that the European Food Safety Authority completed its review of S6973, allowing usage in the European Union as of March 2014.

Commercialization activities with S6973 are being conducted in the Americas, Southeast Asia, Africa, and Australia by Senomyx’s partner, Firmenich. Market launches of retail products that incorporate S6973 have occurred in the U.S., Latin America, Asia, and South Africa. These products span a variety of categories including ready-to-drink and powdered beverages, dairy products, and baked goods.

Sweetmyx SR69 was added to Senomyx’s direct sales portfolio as of the second quarter of 2014. Initial introductions of SR69 to flavor companies, with a focus on usage for food product categories, are underway.

Sweetmyx SR69 was added to Senomyx’s direct sales portfolio as of the second quarter of 2014. Initial introductions of SR69 to flavor companies are underway.

Senomyx’s Sweetmyx SR96 (S9632) has been granted a FEMA GRAS regulatory designation and most recently received a positive determination from JECFA in 2014. Like SR69, SR96 can be used to restore the desired taste profile of products in which in which sucrose has been reduced, providing a solution for manufacturers seeking to create new offerings that have significantly lower sugar and calories, but retain the sugar taste consumers enjoy. SR96 is applicable for use in alcoholic beverages, as well as a broader range of non-alcoholic beverages that includes powdered and concentrated beverages, along with ready-to-drink and powdered forms of dairy, coffee and tea products.

Sweetmyx SR96 is being marketed under Senomyx’s direct sales program. It is currently being demonstrated to flavor companies for end-use in non-alcoholic beverages and powdered beverages. Firmenich has exclusive rights during their “period of exclusivity” to commercialize SR96 for food applications and shares co-exclusive rights with Senomyx for powdered beverages.

Sweetmyx S617, a new modifier intended for use in products that have reduced high fructose corn syrup (HFCS) or sucrose, was granted FEMA GRAS regulatory status in March 2014. High fructose corn syrup is a widely used sweetener, especially in North America. It is used in products such as baked goods, yogurts, sauces and condiments, beverages and concentrates, granola and energy bars, and canned and frozen fruits. The utility of Sweetmyx S617 with both HFCS and sucrose could allow manufacturers that use these sweeteners to focus their internal efforts on a single sweet taste modifier, thereby potentially increasing efficiency and cost-effectiveness.

The goal of the Natural Products Initiative of Senomyx’s Sweet Taste Program is to discover and develop novel no- or low-calorie natural high intensity sweeteners and natural sweet taste modifiers. The Company has identified several natural products from plant sources that function as flavors with modifying properties and natural high intensity sweeteners, which have validated our approach for this program.

Bitter Blockers Program
The primary goals of Senomyx's Bitter Blocker Program are to reduce or block bitter taste and to improve the overall taste characteristics of foods, beverages, and ingredients. Reducing bitterness would be valuable for the many manufacturers who want to improve the taste characteristics of foods, beverages, healthcare items, and other products.

Senomyx received FEMA GRAS regulatory designations for two Bitter Blockers, S6821 and S7958, as well as positive JECFA determinations. S6821 has demonstrated activity against bitter tasting foods and beverages that include soy and whey proteins, menthol, caffeine, cocoa, and Rebaudioside A (stevia). S7958, a related bitter blocker with similar functionality, has alternative desirable physical properties that may be useful for these or other product applications.

A Senomyx partner is marketing retail products incorporating S6821 in a country in Southeast Asia. The partner is also evaluating the use of S6821 in additional products and geographies.

Senomyx initiated market introductions of Bittermyx BB68 (S6821) as part of our direct sales program during the first quarter of 2014.

Salt Taste Program
The goal of our Salt Taste Program is to identify flavor ingredients that allow a significant reduction of sodium in foods and beverages yet maintain the salty taste desirable to consumers. This program is an important research focus for the Company’s longer-term pipeline. Senomyx has assembled a proprietary database of proteins found in taste buds and progress is being made exploring the role of a number of these proteins that may be involved in salt taste perception. This protein or proteins can then serve as research targets to discover new salt flavor modifiers using Senomyx’s novel flavor technology. In April 2014, Senomyx entered into a new collaborative agreement under which PepsiCo will provide research funding to support the Salt Taste Program.

Cooling Taste Program
The goal of Senomyx’s Cooling Taste Program is to identify novel cooling agents that do not have the limitations of currently available agents, which include weak cooling characteristics, bitter off-tastes, limited solubility, and non-proprietary status. S2227, Senomyx’s new cooling agent, was granted FEMA GRAS status during the second quarter of 2014. The FEMA GRAS designation permits usage in the U.S. and elsewhere for a variety of product categories including confectionaries, sauces, beverages, and dairy products. Firmenich has exclusive commercialization rights for S2227 and is currently evaluating these cooling agents for potential future commercialization. Senomyx is evaluating additional new cooling agents for potential future commercialization.


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