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SAN DIEGO, CA (June 21, 2004) – Senomyx, Inc. (Nasdaq: SNMX) today announced the pricing of its initial public offering of 6,000,000 shares of common stock at a price of $6.00 per share. All of the shares are being offered by Senomyx. Senomyx also granted to the underwriters a thirty-day option to purchase up to an additional 900,000 shares of common stock to cover over-allotments. The shares have been listed on The Nasdaq National Market under the symbol "SNMX."

Citigroup will be acting as the sole book-runner of this offering. Deutsche Bank Securities will be a co-lead manager. Needham & Company, Inc. and First Albany Capital will be co-managers of the offering.

The public offering is being made only by means of a prospectus. Copies of the final prospectus relating to the offering can be obtained from Citigroup Global Markets Inc. (Prospectus Department, 140 58th Street, Brooklyn, NY 11220, Fax: (718) 765-6734).

A registration statement relating to these securities was filed with and has been declared effective by the Securities and Exchange Commission. This press release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of these securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such jurisdiction.

About Senomyx, Inc.

Senomyx, Inc. is a biotechnology company using proprietary taste receptor-based assays and screening technologies to discover and develop novel flavors and flavor enhancers for the packaged food and beverage industry.

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