News

SENOMYX, INC. THIRD QUARTER CONFERENCE CALL SCHEDULED FOR OCTOBER 28, 2004

LA JOLLA, CA, October 21, 2004 - Senomyx, Inc. (NASDAQ: SNMX) will host an update conference call with live Internet broadcast to provide a business update, a review of third quarter and year to date results and financial guidance on Thursday, October 28, 2004 at 8:00 AM (EDT).

The conference call is being webcast and can be accessed through the Investor Relations section of Senomyx's homepage, www.senomyx.com. Investors can also listen to the call at www.fulldisclosure.com or call 1-800-688-0836 (U.S.) or 1-617-614-4072 (international) and dial the participant passcode 50422857 to access the call.

About Senomyx, Inc. (www.senomyx.com)

Senomyx is a biotechnology company using proprietary taste receptor-based assays, screening technologies and optimization chemistry to discover and develop novel flavor enhancers and taste modulators for the packaged food and beverage industry. Senomyx has entered into product discovery and development collaborations with four of the world's leading packaged food and beverage companies: Campbell Soup Company, The Coca-Cola Company, Kraft Foods Global, Inc. and Nestlé SA. Senomyx's current programs focus on the development of flavor enhancers and taste modulators in taste areas including savory, sweet and salt.

Contacts:

Finance		Investor Relations
		Susan Neath
John Poyhonen		Atkins + Associates
Senomyx, Inc.		858-527-3486
858-646-8302		sneath@irpr.com