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SENOMYX TO WEBCAST CORPORATE PRESENTATION AT THE SG COWEN 25TH ANNUAL HEALTH CARE CONFERENCE

La Jolla, CA - March 10, 2005 - Senomyx, Inc. (NASDAQ: SNMX) announced today that the Company's Chief Scientific Officer and Senior Vice President of Research, Mark Zoller, Ph.D., will present a corporate overview on Wednesday, March 16, 2005 at 3:10 PM Eastern Time (12:10 p.m. Pacific Time) during the SG Cowen & Co. 25th Annual Healthcare Conference. The conference is taking place at The Boston Marriott Copley Place in Boston, Massachusetts. During his presentation, Dr. Zoller will provide an overview of the Company's pipeline of novel flavor enhancers and taste modulators and a product development update.

To access the live presentation or a subsequent archived recording please log onto Senomyx's website at http://www.senomyx.com and click on the "Investor Relations" tab. The archived webcast will be available for 30 days following the presentation. Please connect to Senomyx's website prior to the start of the webcast to ensure adequate time to download any software that may be necessary.

About Senomyx, Inc. (www.senomyx.com)

Senomyx is a biotechnology company using proprietary taste receptor-based assays, screening technologies and optimization chemistry to discover and develop novel flavor enhancers and taste modulators for the packaged food and beverage industry. Senomyx has entered into product discovery and development collaborations with four of the world's leading packaged food and beverage companies: Campbell Soup Company, The Coca-Cola Company, Kraft Foods Global, Inc. and Nestlé SA. Senomyx's current programs focus on the development of flavor enhancers and taste modulators in taste areas including savory, sweet, salt and bitter.