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SENOMYX TO WEBCAST CORPORATE PRESENTATION AT THE SMITH BARNEY CITIGROUP 2005 HEALTHCARE CONFERENCE

La Jolla, CA - March 23, 2005 - Senomyx, Inc. (NASDAQ: SNMX) announced today that the Company's President and CEO, Kent Snyder, will present a corporate overview on Tuesday, March 29, 2005 at 4:30 p.m. Eastern Time (1:30 p.m. Pacific Time) during the Smith Barney Citigroup 2005 Healthcare Conference. The conference is taking place at The Mayflower Hotel in Washington DC. During his presentation, Mr. Snyder will provide an overview of the Company's pipeline of novel flavor enhancers and taste modulators and a product development update.

To access the live presentation or a subsequent archived recording please log onto Senomyx's website at http://www.senomyx.com and click on the "Investor Relations" tab. The archived webcast will be available for 30 days following the presentation. Please connect to Senomyx's website prior to the start of the webcast to ensure adequate time to download any software that may be necessary.

About Senomyx

Senomyx is a biotechnology company using proprietary taste receptor-based assays, screening technologies, and optimization chemistry to discover and develop novel flavor enhancers and taste modulators for the packaged food and beverage industry. Senomyx's current programs focus on the development of flavor enhancers and taste modulators in four taste areas: savory, sweet, salt and bitter. Senomyx has entered into product discovery and development collaborations with four of the world's leading packaged food and beverage companies: Campbell Soup Company, The Coca-Cola Company, Kraft Foods Global, Inc. and Nestlé SA.