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MICHAEL E. HERMAN ELECTED TO THE BOARD OF DIRECTORS OF SENOMYX, INC.


LA JOLLA, CA - June 1, 2005 - Senomyx, Inc. (NASDAQ: SNMX) announced today that Michael E. Herman was elected to the Company's Board of Directors at the Company's 2005 Annual Meeting of Stockholders, held on May 25, 2005.

"We are pleased to welcome Mike Herman to our Board of Directors. Mike brings a wealth of relevant knowledge and experience to Senomyx. His background includes extensive experience in the life sciences and health care industries, financial transactions, and public company Board experience. We look forward to working closely with Mike as we advance our discovery and development efforts toward product commercialization," said Kent Snyder, President and Chief Executive Officer of Senomyx.

"I am pleased to be joining the Senomyx Board of Directors at this very exciting stage in the company's history. Senomyx has access to sizable markets through its collaborations with the world's leading food and beverage companies. The novel flavors, flavor enhancers and taste modulators that Senomyx is developing have the potential to improve the nutritional profile of many packaged food and beverage products used around the world," said Mr. Herman.

Mr. Herman is currently serving as general partner of the Herman Family Trading Company. From January 1992 to December 2000, Mr. Herman was President of the Kansas City Royals Baseball Club. From January 1990 to December 1999, he was Chairman of the Finance and Investment Committee of the Kauffman Foundation and was its President from January 1985 to December 1990. From October 1974 to December 1990, Mr. Herman was the Executive Vice President and Chief Financial Officer of Marion Laboratories. Mr. Herman is a director of Santarus, Inc., a biopharmaceutical company, Cerner Corporation, a health care information technology company, and also is a Trustee of Rensselaer Polytechnic Institute and the University of Chicago Graduate School of Business. Mr. Herman also served as a director of Janus Capital and Eloquent, Inc. until March of 2003. Additionally, Mr. Herman previously served on the Board of Directors of Agouron Pharmaceuticals, Circon, Inc., Marion Labs, Nordic Labs and Tanabe-Marion Labs, Inc.

Mr. Herman earned his Bachelors of Science degree in Metallurgical Engineering from Rensselaer Polytechnic Institute and his MBA from the University of Chicago.

In addition to the election of Mr. Herman, the company also announced that Steven Block, Esq., Mark Leschly, David Schnell, M.D., Jay Short, Ph.D., Kent Snyder and Timothy Wollaeger were re-elected to the Board of Directors at the Annual Meeting.

About Senomyx, Inc. (www.senomyx.com)

Senomyx is a biotechnology company using proprietary taste receptor-based assays, screening technologies and optimization chemistry to discover and develop novel flavors, flavor enhancers and taste modulators for the packaged food and beverage industry. Senomyx's current programs focus on the development of flavors, flavor enhancers and taste modulators in the savory, sweet, salt and bitter taste areas. Senomyx has entered into product discovery and development collaborations with four of the world's leading packaged food and beverage companies: Campbell Soup Company, The Coca-Cola Company, Kraft Foods Global, Inc. and Nestlé SA.

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Financial:   Investor Relations:
John Poyhonen   Susan Neath
Vice President & CFO, CBO   Atkins + Associates
Senomyx, Inc.   Media & Investor Relations
858-646-8302   858-527-3486 

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