News

SENOMYX, INC. THIRD QUARTER EARNINGS CONFERENCE CALL SCHEDULED FOR OCTOBER 20, 2005

LA JOLLA, CA - October 13, 2005 - Senomyx, Inc. (NASDAQ: SNMX) will release its third quarter and year to date 2005 financial results on Thursday, October 20 before the opening of the U.S. financial markets. The Company will also host a conference call with live Internet broadcast to provide a business update and a review of third quarter and year to date results the same day at 11:00 a.m. Eastern Time (8:00 a.m. Pacific Time).

To participate in the live conference call, U.S. residents should dial 866-203-2528, and international callers should dial 617-213-8847. The participant passcode for this conference call is 26728473.

To access the live Internet broadcast or a subsequent archived recording please log onto Senomyx's website at http://www.senomyx.com and click on the "Investor Relations" tab. The archived webcast will be available for 30 days following the presentation. Please connect to Senomyx's website prior to the start of the webcast to ensure adequate time to download any software that may be necessary.

About Senomyx, Inc. (www.senomyx.com)

Senomyx is a biotechnology company using proprietary taste receptor-based assays, screening technologies and optimization chemistry to discover and develop novel flavors, flavor enhancers and taste modulators for the packaged food and beverage industry. Senomyx's current programs focus on the development of flavors, flavor enhancers and taste modulators in the savory, sweet, salt and bitter taste areas. Senomyx has entered into product discovery and development collaborations with five of the world's leading packaged food and beverage companies: Cadbury Schweppes, Campbell Soup Company, The Coca-Cola Company, Kraft Foods Global, Inc. and Nestlé SA.

Contacts

John Poyhonen		Gwen Rosenberg
VP, Chief Financial & Business Officer		Executive Director, Corporate Communications & Investor Relations
Senomyx, Inc.		Media & Senomyx, Inc.
858-646-8302		858-646-8369
john.poyhonen@senomyx.com		gwen.rosenberg@senomyx.com